| First Author | Dietrich HM | Year | 1996 |
| Journal | Lab Anim | Volume | 30 |
| Issue | 2 | Pages | 102-7 |
| PubMed ID | 8783169 | Mgi Jnum | J:34015 |
| Mgi Id | MGI:81493 | Doi | 10.1258/002367796780865754 |
| Citation | Dietrich HM, et al. (1996) Isolation of Enterococcus durans and Pseudomonas aeruginosa in a scid mouse colony. Lab Anim 30(2):102-7 |
| abstractText | In a colony of severe combined immunodeficiency (SCID) mice conspicuously altered behavioural characteristics were observed: hunched position, apathy, dullness, short breath, bristled fur, emaciation, circling movements around their longitudinal axis and oblique head posture. This was most common in pregnant and lactating animals and also observed in 4 mice after experimental treatment. Pseudomonas aeruginosa, serotype P1 and Enterococcus durans, serotype D were isolated from various organs and from the middle ear. On autopsy, the mice showed signs of focal pericarditis and thickened liver capsules. The histological examination of the liver revealed mild, focal accumulations of mononuclear cells. In addition, it was observed that SCID mice with signs of this disease did not allow human peripheral blood mononuclear cells to engraft. |
