| First Author | Schnyder S | Year | 2017 |
| Journal | Am J Physiol Endocrinol Metab | Volume | 312 |
| Issue | 5 | Pages | E437-E446 |
| PubMed ID | 28223292 | Mgi Jnum | J:244935 |
| Mgi Id | MGI:5913714 | Doi | 10.1152/ajpendo.00361.2016 |
| Citation | Schnyder S, et al. (2017) Muscle PGC-1alpha is required for long-term systemic and local adaptations to a ketogenic diet in mice. Am J Physiol Endocrinol Metab 312(5):E437-E446 |
| abstractText | Low-carbohydrate/high-fat (LCHF) diets are increasingly popular dietary interventions for body weight control and as treatment for different pathological conditions. However, the mechanisms of action are still poorly understood, in particular, in long-term administration. Besides liver, brain, and heart, skeletal muscle is one of the major organs involved in the regulation of physiological and pathophysiological ketosis. We assessed the role of the peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) in skeletal muscle of male wild-type control and PGC-1alpha muscle-specific knockout mice upon 12 wk of LCHF diet feeding. Interestingly, LCHF diet administration increased oxygen consumption in a muscle PGC-1alpha-dependent manner, concomitant with a blunted transcriptional induction of genes involved in fatty acid oxidation and impairment in exercise performance. These data reveal a new role for muscle PGC-1alpha in regulating the physiological adaptation to long-term LCHF diet administration. |
