| Primary Identifier | MGI:2135607 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 93759 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables several functions, including NAD-dependent histone H3K9 deacetylase activity; p53 binding activity; and transcription coregulator activity. Involved in several processes, including regulation of cellular biosynthetic process; regulation of fat cell differentiation; and regulation of signal transduction. Acts upstream of or within several processes, including behavioral response to starvation; cellular response to leukemia inhibitory factor; and negative regulation of macromolecule biosynthetic process. Located in mitochondrion and nucleus. Part of heterochromatin. Is expressed in several structures, including brain; gonad; heart; metanephros; and sensory organ. Used to study Alzheimer's disease; nephrogenic diabetes insipidus; and steatotic liver disease. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Orthologous to human SIRT1 (sirtuin 1). PHENOTYPE: Mice homozygous for a knock-out allele show embryonic and fetal lethality, abnormal embryogenesis, and abnormal cellular phenotypes of derived MEFs. Mice homozygous for other knock-out alleles may exhibit peri- and postnatal lethality and heart, mammary gland, eye, and reproductive system anomalies. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
