| Primary Identifier | MGI:1261758 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 52615 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables chromatin binding activity and nucleic acid binding activity. Involved in facultative heterochromatin formation. Acts upstream of or within several processes, including negative regulation of macromolecule biosynthetic process; oligodendrocyte differentiation; and positive regulation of cell population proliferation. Located in nucleus. Part of nucleus; ribonucleoprotein complex; and sex chromatin. Is expressed in several structures, including bone; branchial arch; central nervous system; limb bud; and sensory organ. Human ortholog(s) of this gene implicated in renal Wilms' tumor. Orthologous to human SUZ12 (SUZ12 polycomb repressive complex 2 subunit). PHENOTYPE: Homozygous null mice die during early postimplantation stages with failure of embryonic and extraembyronic tissues and organogenesis. Mice heterozygous for a knock-out allele exhibit abnormal brain and spinal cord development with varying penetrance. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
