| Primary Identifier | MGI:106544 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 227695 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable miRNA binding activity. Predicted to be involved in maintenance of centrosome location and miRNA processing. Predicted to act upstream of with a positive effect on post-transcriptional regulation of gene expression. Predicted to act upstream of or within cell division and methylation. Predicted to be located in chromosome, centromeric region; cytoplasm; and cytoskeleton. Predicted to be active in kinetochore; mitotic spindle; and spindle pole centrosome. Is expressed in embryo and extraembryonic component. Orthologous to human SPOUT1 (SPOUT domain containing methyltransferase 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality before implantation. Heterozygotes show reduced spontaneous apoptosis of differentiating spermatogonia as well as reduced apoptosis and nuclear DNA fragmentation in splenocytes, thymocytes and MEFs in response to apoptotic stimuli. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
