| First Author | Kimura D | Year | 2016 |
| Journal | Immunity | Volume | 44 |
| Issue | 3 | Pages | 672-682 |
| PubMed ID | 26968425 | Mgi Jnum | J:254631 |
| Mgi Id | MGI:6112268 | Doi | 10.1016/j.immuni.2016.02.011 |
| Citation | Kimura D, et al. (2016) Interleukin-27-Producing CD4(+) T Cells Regulate Protective Immunity during Malaria Parasite Infection. Immunity 44(3):672-682 |
| abstractText | Interleukin-27 (IL-27) is a heterodimeric regulatory cytokine of the IL-12 family, which is produced by macrophages, dendritic cells, and B cells upon stimulation through innate immune receptors. Here, we described regulatory CD4(+) T cells that produce IL-27 in response to T cell receptor stimulation during malaria infection, inhibiting IL-2 production and clonal expansion of other T cells in an IL-27-dependent manner. IL-27-producing CD4(+) T cells were Foxp3(-)CD11a(+)CD49d(+) malaria antigen-specific CD4(+) T cells and were distinct from interferon-gamma (IFN-gamma) producing Th1 or IL-10 producing Tr1 cells. In mice lacking IL-27 in T cells, IL-2 production was restored and clonal expansion and IFN-gamma production by specific CD4(+) T cells were improved, culminating in reduced parasite burden. This study highlights a unique population of IL-27 producing regulatory CD4(+) T cells and their critical role in the regulation of the protective immune response against malaria parasites. |
