| First Author | Tao L | Year | 2000 |
| Journal | Cancer Lett | Volume | 158 |
| Issue | 2 | Pages | 185-93 |
| PubMed ID | 10960769 | Mgi Jnum | J:64672 |
| Mgi Id | MGI:1889765 | Doi | 10.1016/s0304-3835(00)00518-8 |
| Citation | Tao L, et al. (2000) Hypomethylation and overexpression of c-jun and c-myc protooncogenes and increased DNA methyltransferase activity in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors. Cancer Lett 158(2):185-93 |
| abstractText | Dichloroacetic acid (DCA) and trichloroacetic acid (TCA) are mouse liver carcinogens. Methylation of the c-jun and c-myc genes, expression of both genes and DNA methyltransferase (DNA MTase) activity were determined in liver tumors initiated by N-methyl-N-nitrosourea and promoted by DCA and TCA in female B6C3F1 mice. Hypomethylated and over-expression of c-jun and c-myc genes were found in DCA- and TCA-promoted liver tumors. DNA MTase activity was increased in tumors while decreased in non-involved liver. Thus, DCA- and TCA-promoted carcinogenesis appears to include decreased methylation and increased expression of c-jun and c-myc genes in the presence of increased DNA MTase activity. |
