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MP Term : decreased circulating CXCL10 level [MP:0031219] Mammalian Phenotype

Namespace  MPheno.ontology Obsolete  false
description  reduction in the blood levels of CXCL10 protein, a pro-inflammatory cytokine that is secreted by a wide range of cell types in response to interferon-gamma, and produces its effects by binding to the cell surface chemokine receptor CXCR3; this chemokine is involved in a variety of processes including chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects, and plays an important role during viral infections by stimulating the activation and migration of immune cells to infected sites
  • synonyms:
  • decreased circulating small-inducible cytokine B10 level,
  • decreased circulating interferon gamma-induced protein 10 level,
  • decreased circulating IP10 level,
  • decreased circulating C-X-C motif chemokine ligand 10 level,
  • reduced circulating CXCL10 level,
  • decreased circulating IFN gamma-inducible protein 10 level,
  • decreased circulating gamma-IP10 level,
  • decreased circulating IP-10 level
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Phenotype

Mammalian phenotypes (MP terms) --> Mouse genes and models

Ontology

Ontology Term --> All ancestors

Ontology Term --> All descendants

Ontology Term --> Direct children

Ontology Term --> Direct parents