| Primary Identifier | MGI:4889225 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Dct-mHELKK)1Rc |
| Strain of Origin | C57BL/6 and CBA/Ca | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Mice bearing this transgene express intracellular, membrane-bound hen egg lysozyme. Expression is driven specifically in melanocytes by the mouse dopachrome tautomerase (Dct; formerly Trp2) promoter. The lysozyme protein is anchored within the endoplasmic reticulum (ER) by the H2-kb transmembrane domain that has been modified by addition of a dilysine ER retention signal. Two transgenic lines, designated TrpHEL1 and TrpHEL2, exhibited similar levels of expression in both skin and thymus, colocalized in skin with endogenous DCT. |
