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Protein Coding Gene : St6galnac4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4

Primary Identifier  MGI:1341894 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  20448
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. Predicted to be involved in ganglioside biosynthetic process and oligosaccharide metabolic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in Golgi apparatus and membrane. Is expressed in several structures, including alimentary system; central nervous system; hemolymphoid system; integumental system; and sensory organ. Orthologous to human ST6GALNAC4 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4).
PHENOTYPE: Mice homozygous for a null allele exhibit no abnormal phenotype. Double homozygotes lacking St6galnac3 and St6galnac4 exhibit lymph node hemorrhage associated with structural disruption of high endothelial venule. [provided by MGI curators]
  • synonyms:
  • sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) D,
  • St6galnac4,
  • ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4,
  • ST6GalNAc IV,
  • Siat7d

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