| First Author | Loscher CE | Year | 2003 |
| Journal | J Neuroimmunol | Volume | 137 |
| Issue | 1-2 | Pages | 117-24 |
| PubMed ID | 12667655 | Mgi Jnum | J:129159 |
| Mgi Id | MGI:3768751 | Doi | 10.1016/s0165-5728(03)00072-9 |
| Citation | Loscher CE, et al. (2003) Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type I receptor. J Neuroimmunol 137(1-2):117-24 |
| abstractText | Interleukin-1 receptor antagonist (IL-1ra) selectively and competitively inhibits the actions of IL-1 at its receptors and has not been reported to have agonist activity. This study demonstrates that stimulation of synaptosomes with IL-1ra in vitro, mimicked the effects of IL-1 beta by decreasing glutamate release and increasing JNK phosphorylation. These effects of IL-1ra, but not IL-1 beta, were maintained in IL-1 type I receptor (IL-1RI) defective mice. IL-1 beta blocked these IL-1ra-induced effects suggesting that it may also act independently of IL-1RI in some circumstances. Furthermore, IL-1ra mimicked the inhibitory effect of IL-1 beta on long-term potentiation (LTP) in the hippocampus. These data, taken together with our findings that IL-1ra binds to hippocampal synaptosomes in the absence of IL-1RI, provide evidence that IL-1ra exerts agonist activity in the hippocampus independent of IL-1RI. |
