| Primary Identifier | IPR009976 | Type | Family |
| Short Name | Sec10-like |
| description | This family contains the Sec10 component (approximately 650 residues long) of the eukaryotic exocyst complex, which mediates the tethering of post-Golgi secretory vesicles to the plasma membrane and promotes the assembly of the SNARE complex for membrane fusion [, , ]. It is also involved in cell polarisation, primary ciliogenesis, cytokinesis, pathogen invasion, tumorigenesis and metastasis. The exocyst is a member of the Complex Associated with Tethering Containing Helical Rods (CATCHRs) which also includes DSL1, COG and GARP complexes, evolutionary related. They share structural features comprising α-helical bundles towards the C-terminal and coiled-coil regions at the N-terminal. It also includes Recyclin-1 and protein Pof6. Recyclin-1 is involved in recycling plasma membrane proteins internalized by endocytosis [, ]. Pof6, together with skp1, is essential for septum processing and cell separation []. |
