| Primary Identifier | MGI:6193754 | Allele Type | Transgenic |
| Attribute String | Knockdown | Gene | Tg(RNU6-1-RNAi:Cdk5)#Chad |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The human U6 small nuclear RNA gene promoter was used to drive expression of a mouse anti-Cdk5 shRNA. The construct was microinjected into the male pronuclei of C57BL/6J zygotes. Three founders were generated. Immunohistochemical and Western blot analyses confirmed that protein expression was decreased in the skin of knockdown mice relative to wild-type controls. The pound symbol (#) is used when no line is specified and/or lines are pooled. |
