Primary Identifier | MGI:7462664 | Allele Type | Targeted |
Gene | F3 | Transmission | Germline |
Strain of Origin | 129P2/OlaHsd | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The coding region was replaced with a cDNA of the mouse gene containing a C213G mutation in exon 5 and a floxed neo cassette in inverse orientation via homologous recombination. This mutation disrupts the extracellular allosteric disulfide bond (Cys190-Cys213). |