| First Author | Balmus G | Year | 2016 |
| Journal | Genes Dev | Volume | 30 |
| Issue | 19 | Pages | 2152-2157 |
| PubMed ID | 27798842 | Mgi Jnum | J:236776 |
| Mgi Id | MGI:5807276 | Doi | 10.1101/gad.290510.116 |
| Citation | Balmus G, et al. (2016) Synthetic lethality between PAXX and XLF in mammalian development. Genes Dev 30(19):2152-2157 |
| abstractText | PAXX was identified recently as a novel nonhomologous end-joining DNA repair factor in human cells. To characterize its physiological roles, we generated Paxx-deficient mice. Like Xlf-/- mice, Paxx-/- mice are viable, grow normally, and are fertile but show mild radiosensitivity. Strikingly, while Paxx loss is epistatic with Ku80, Lig4, and Atm deficiency, Paxx/Xlf double-knockout mice display embryonic lethality associated with genomic instability, cell death in the central nervous system, and an almost complete block in lymphogenesis, phenotypes that closely resemble those of Xrcc4-/- and Lig4-/- mice. Thus, combined loss of Paxx and Xlf is synthetic-lethal in mammals. |
