| First Author | Descamps O | Year | 2005 |
| Journal | Mech Ageing Dev | Volume | 126 |
| Issue | 11 | Pages | 1185-91 |
| PubMed ID | 16126250 | Mgi Jnum | J:101678 |
| Mgi Id | MGI:3604446 | Doi | 10.1016/j.mad.2005.06.007 |
| Citation | Descamps O, et al. (2005) Mitochondrial production of reactive oxygen species and incidence of age-associated lymphoma in OF1 mice: Effect of alternate-day fasting. Mech Ageing Dev 126(11):1185-91 |
| abstractText | There is currently of a great interest investigating the role of nutrition in the prevention of age-associated disorders. The present study aimed to evaluate, on a particular strain of mice, the efficacy of alternate-day fasting on the mitochondrial production of free radical species and on the incidence of a specific cancer (lymphoma) in aged mice. Alternate fasting, that was initiated in middle age mice through a 4 month period, reduced significantly the incidence of lymphoma (0% versus 33% for controls). No remarkable difference was observed in the overall food consumption between alternate-fed (AF) and ad libitum (AL) mice, suggesting that the efficacy of alternate fasting did not really depend on calorie restriction. A significant decrease in the mitochondrial generation of reactive oxygen species (ROS) that was associated with a significant increase in spleen mitochondria SOD activity was observed when mice were maintained on intermittent fasting. Our results suggest that alternate fasting could exert a beneficial antioxidant effect and a modulation of the oxidative stress associated with aging. |
