| First Author | Francosalinas G | Year | 2013 |
| Journal | J Neuroimmunol | Volume | 255 |
| Issue | 1-2 | Pages | 8-17 |
| PubMed ID | 23137837 | Mgi Jnum | J:309908 |
| Mgi Id | MGI:6708234 | Doi | 10.1016/j.jneuroim.2012.10.010 |
| Citation | Francosalinas G, et al. (2013) Enhanced costimulation by CD70+ B cells aggravates experimental autoimmune encephalomyelitis in autoimmune mice. J Neuroimmunol 255(1-2):8-17 |
| abstractText | OBJECTIVE: Assess whether CD70+ B cells contribute to EAE. MATERIALS AND METHODS: MOG-specific TCR transgenic mice (2D2) were crossed with mice with constitutive CD70 expression on B cells. The development of EAE and the phenotype of B-T lymphocytes were studied in 2D2xCD70 animals. RESULTS: Spontaneous EAE developed in 20% of 2D2xCD70 and 3% of 2D2 mice. EAE was also more severe in 2D2xCD70 versus 2D2 animals upon MOG immunization. The susceptibility of 2D2xCD70 to EAE was associated with fewer FoxP3+ T cells. CONCLUSIONS: Expression of CD70 by B cells aggravates EAE possibly by reducing the number of regulatory T cells. |
