| Primary Identifier | MGI:1354949 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 50768 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable several functions, including GTPase activator activity; SH2 domain binding activity; and phospholipase binding activity. Acts upstream of or within several processes, including actin cytoskeleton organization; focal adhesion assembly; and nervous system development. Predicted to be located in several cellular components, including caveola; cortical actin cytoskeleton; and ruffle membrane. Predicted to be active in focal adhesion and membrane raft. Predicted to colocalize with actin filament and stress fiber. Is expressed in several structures, including alimentary system; central nervous system; heart; hemolymphoid system gland; and placenta. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human DLC1 (DLC1 Rho GTPase activating protein). PHENOTYPE: Homozygous mutants die by E10.5 with variable defects in the neural tube, heart, brain and placenta. Mouse embryonic fibroblasts homozygous for an activated conditional allele exhibti increased sensitivity to Ras-induced transformation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
