| First Author | Ebihara S | Year | 1987 |
| Journal | Brain Res | Volume | 416 |
| Issue | 1 | Pages | 136-40 |
| PubMed ID | 3620949 | Mgi Jnum | J:27126 |
| Mgi Id | MGI:74544 | Doi | 10.1016/0006-8993(87)91505-8 |
| Citation | Ebihara S, et al. (1987) Pineal indole metabolism in the mouse. Brain Res 416(1):136-40 |
| abstractText | The activity of two pineal enzymes serotonin N-acetyltransferase (SNAT) and hydroxyindole-O-methyltransferase, (HIOMT) and the pineal content of serotonin (5-HT) and N-acetylserotonin (NAS) were measured in several strains of mice (Mus domesticus) in order to compare melatonin synthetic pathways among them. Of the strains we examined, C57BL/6J, AKR/J, BALB/c, NZB/BLNJ and wild mice, only wild mice synthesize pineal melatonin. Wild mice had high activity of both SNAT and HIOMT; NZB had SNAT activity but did not have HIOMT; the three other strains had neither SNAT nor HIOMT; the activity of SNAT in wild mice showed a clear daily rhythm but HIOMT activity did not show any significant daily changes. The pineal content of 5-HT in wild and NZB mice was higher during the day than during the night, however in C57BL and AKR, 5-HT levels were higher during the night than during the day. As expected NAS was found in wild and NZB mice. |
