| First Author | Xu Y | Year | 2003 |
| Journal | Nat Immunol | Volume | 4 |
| Issue | 12 | Pages | 1177-82 |
| PubMed ID | 14608382 | Mgi Jnum | J:86605 |
| Mgi Id | MGI:2680853 | Doi | 10.1038/ni1008 |
| Citation | Xu Y, et al. (2003) Deletion of beta-catenin impairs T cell development. Nat Immunol 4(12):1177-82 |
| abstractText | T cells encounter two main checkpoints during development in the thymus. These checkpoints are critically dependent on signals derived from the thymic microenvironment as well as from the pre-T cell receptor (pre-TCR) and the alphabeta TCR. Here we show that T cell-specific deletion of beta-catenin impaired T cell development at the beta-selection checkpoint, leading to a substantial decrease in splenic T cells. In addition, beta-catenin also seemed to be a target of TCR-CD3 signals in thymocytes and mature T cells. These data indicate that beta-catenin-mediated signals are required for normal T cell development. |
