| First Author | Oh WJ | Year | 2013 |
| Journal | Neuron | Volume | 80 |
| Issue | 2 | Pages | 458-69 |
| PubMed ID | 24139045 | Mgi Jnum | J:207212 |
| Mgi Id | MGI:5554666 | Doi | 10.1016/j.neuron.2013.09.005 |
| Citation | Oh WJ, et al. (2013) Establishment of neurovascular congruency in the mouse whisker system by an independent patterning mechanism. Neuron 80(2):458-69 |
| abstractText | Nerves and vessels often run parallel to one another, a phenomenon that reflects their functional interdependency. Previous studies have suggested that neurovascular congruency in planar tissues such as skin is established through a "one-patterns-the-other" model, in which either the nervous system or the vascular system precedes developmentally and then instructs the other system to form using its established architecture as a template. Here, we find that, in tissues with complex three-dimensional structures such as the mouse whisker system, neurovascular congruency does not follow the previous model but rather is established via a mechanism in which nerves and vessels are patterned independently. Given the diversity of neurovascular structures in different tissues, guidance signals emanating from a central organizer in the specific target tissue may act as an important mechanism to establish neurovascular congruency patterns that facilitate unique target tissue function. |
