Primary Identifier | MGI:2176375 | Organism | mouse, laboratory |
Chromosome | 9 | NCBI Gene Number | 171530 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables G protein-coupled receptor binding activity. Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; hormone-mediated signaling pathway; and negative regulation of gonadotropin secretion. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human UCN2 (urocortin 2). PHENOTYPE: Female, but not male, mice homozygous for a null allele show a significant increase in the basal daily rhythms of ACTH and corticosterone, altered drinking and feeding responses, and increased antidepressant-like behavior. Mice homozygous for a second null allele show normal social memory. [provided by MGI curators] |