| Primary Identifier | IPR042082 | Type | Homologous_superfamily |
| Short Name | CST_Stn1_wHTH1_sf |
| description | Stn1 is a component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites [, ]. The C-terminal domain of Stn1 has two winged helix-turn-helix (wHTH) motifs, wHTH1 and wHTH2. This superfamily represents the wHTH1 motif, which is structurally similar to that in RPA32 with an additional large insertion between helices α2 and α3, unique to Stn1 [, ]. This additional wHTH1 motif may allow interaction with a different set of proteins that function at telomeres such as Ctc1 []. |
