| Primary Identifier | MGI:2447604 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(IghMyc)22Bri |
| Strain of Origin | (C57BL x SJL)F2 | Is Recombinase | false |
| Is Wild Type | false |
| description | 13 out of 15 transgenic founders developed lymphomas between 6 and 15 weeks of age. The animals became terminally ill and died or were sacrificed. Hemizygous mice on a C57BL/6 background display increased pre-B cells in the bone marrow throughout life and a transient increase in large pre-B cells in the blood at 3-4 weeks of age. Spontaneous pre-B and B cell lymphomas reach an incidence of 50% at 15-20 weeks in hemizygous progeny of a wildtype female mated with a hemizygous male. In conjuction with Tg(BCL2)22Wehi, transgenic mice on a C57BL/6 background exhibit the production of primitive lymphoid tumors within 5 weeks of birth |
| molecularNote | Expression of the mouse Myc transgene is directed to the B cell lineage by the Igh (E mu) enhancer and Myc promoter. The transgene was originally designated Eμ-Myc. |
