Primary Identifier | IPR029710 | Type | Family |
Short Name | LIG4 |
description | DNA ligase 4 (LIG4) is involved in DNA double-strand break repair []. In higher eukaryotes it forms a complex with XRCC4, which is responsible for the ligation step during the DNA-PK-dependent non-homologous end joining (D-NHEJ) [, ]. The Ku component of the DNA-PK (DNA-dependent protein kinase) complex contributes to the recruitment of the LIG4-XRCC4 complex at the DNA break site []. |