| First Author | O'Brien RL | Year | 2000 |
| Journal | J Immunol | Volume | 165 |
| Issue | 11 | Pages | 6472-9 |
| PubMed ID | 11086087 | Mgi Jnum | J:119306 |
| Mgi Id | MGI:3701738 | Doi | 10.4049/jimmunol.165.11.6472 |
| Citation | O'Brien RL, et al. (2000) Depletion of a gamma delta T cell subset can increase host resistance to a bacterial infection. J Immunol 165(11):6472-9 |
| abstractText | Gammadelta T lymphocytes have been shown to regulate immune responses in diverse experimental systems. Because distinct gammadelta T cell subsets, as defined by the usage of certain TCR V genes, preferentially respond in various diseases and disease models, we have hypothesized that the various gammadelta T cell subsets carry out different functions. To test this, we compared one particular gammadelta T cell subset, the Vgamma1(+) subset, which represents a major gammadelta T cell type in the lymphoid organs and blood of mice, to other subsets and to gammadelta T cells as a whole. Using LISTERIA: monocytogenes infection as an infectious disease model, we found that bacterial containment improves in mice depleted of Vgamma1(+) gammadelta T cells, albeit mice lacking all gammadelta T cells are instead impaired in their ability to control LISTERIA: expansion. Our findings indicate that Vgamma1(+) gammadelta T cells reduce the ability of the innate immune system to destroy LISTERIA:, even though other gammadelta T cells as a whole promote clearance of this pathogen. |
