| Primary Identifier | IPR026280 | Type | Family |
| Short Name | Tissue_plasm_act |
| description | Tissue-type plasminogen activator is a serine peptidase belonging to MEROPS peptidase family S1 (chymotrypsin family, clan PA(S)), subfamily S1A.The fibrinolytic system is the mechanism by which blood clots are dissolved via the plasmin-mediated degradation of fibrin into soluble end products. The system is activated by urokinase-type plasminogen activator (uPA; ) or by tissue-type plasminogen activator (tPA; ; this family), which are enzymes that convert the inactive proenzyme plasminogen to the active protease plasmin [].tPA is mainly involved in the activation of circulating plasminogen, while uPA activates cell-bound plasminogen after binding to a specific uPA receptor (uPAR).Following the signal sequence and propeptide regions, tPA typically contains a fibronectin type I (FN1) domain, an EGF-type domain, two kringle domains and a trypsin domain. However, there are members missing FN1 or EGF or one of the kringles.This entry also includes salivary plaminogen activators from the vampire bat (Desmodus rotundus). |
