| Primary Identifier | IPR000083 | Type | Domain |
| Short Name | Fibronectin_type1 |
| description | Fibronectin type I repeats are one of the three repeats found in the fibronectin protein.Fibronectin is a plasma protein that binds cell surfaces and various compoundsincluding collagen, fibrin, heparin, DNA, and actin. Type I domain (FN1) is approximately40 residues in length. Four conserved cysteines are involved in disulphide bonds. The 3Dstructure of the FN1 domain has been determined [, , ]. It consists of two antiparallelβ-sheets, first a double-stranded one, that is linked by a disulphide bond to atriple-stranded β-sheet. The second conserved disulphide bridge links the C-terminaladjacent strands of the domain.In human tissue plasminogen activator chain A the FN1 domain together with thefollowing epidermal growth factor (EGF)-like domain are involved infibrin-binding []. It has been suggested that these two modules form a single structuraland functional unit []. The two domains keep their specific tertiary structure, but interactintimately to bury a hydrophobic core; the inter-module linker makes up the third strand ofthe EGF-module's major β-sheet. |
