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Protein Coding Gene : Stxbp5 syntaxin binding protein 5 (tomosyn)

Primary Identifier  MGI:1926058 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  78808
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables syntaxin-1 binding activity. Involved in positive regulation of exocytosis; regulation of synaptic vesicle exocytosis; and regulation of synaptic vesicle priming. Acts upstream of or within exocytosis and regulation of exocytosis. Part of acetylcholine-gated channel complex. Is active in hippocampal mossy fiber to CA3 synapse and presynapse. Is extrinsic component of neuronal dense core vesicle membrane. Orthologous to human STXBP5 (syntaxin binding protein 5).
PHENOTYPE: Mice homozygous for a null allele exhibit some background sensitive prenatal lethality and increased synaptic transmission. [provided by MGI curators]
  • synonyms:
  • MGI:2143879,
  • MGI:1921351,
  • 0710001E20Rik,
  • LGL3,
  • Stxbp5,
  • RIKEN cDNA 4930565N16 gene,
  • syntaxin binding protein 5 (tomosyn),
  • mKIAA1006,
  • tomosyn 1,
  • 4930565N16Rik,
  • RIKEN cDNA 0710001E20 gene,
  • expressed sequence AW742610,
  • AW742610

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