| Primary Identifier | IPR039356 | Type | Family |
| Short Name | YfbR/HDDC2 |
| description | Escherichia coli YfbR is a conserved HD-domain-containing protein with orthologues found in bacteria, archaea, and eukaryotes. YfbR shows strict specificity towards deoxyribonucleoside 5'-monophosphates [, ], and has been established as an essential component of the deoxycytidine pathway for de novo synthesis of thymidylate []. The human genome encodes one YfbR orthologue, the uncharacterized HD-domain-containing protein HDDC2. In yeast, HD-domain proteins YGK1 (YGL101W) and YB92 (YBR242W) from Saccharomyces cerevisiae are nucleoside 5'-monophosphatases, with substrate preference for deoxyribonucleoside 5'-monophosphatase over ribonucleoside 5'-monophosphatase []. |
