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Protein Coding Gene : Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma

Primary Identifier  MGI:1349475 Organism  mouse, laboratory
Chromosome  12 NCBI Gene Number  26931
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Predicted to enable protein phosphatase activator activity. Predicted to be involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and negative regulation of cell population proliferation. Predicted to act upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in Golgi apparatus; chromosome, centromeric region; and nucleoplasm. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including central nervous system; eye; genitourinary system; heart; and hemolymphoid system gland. Orthologous to human PPP2R5C (protein phosphatase 2 regulatory subunit B'gamma).
PHENOTYPE: Mice homozygous for a gene-trapped allele show partial neonatal lethality, hypoactivity, and abnormal ventricular septum formation associated with increased fetal cardiomyocyte apoptosis. Surviving homozygotes develop obesity and show an abnormal gait, decreased grip strength, and impaired balance. [provided by MGI curators]
  • synonyms:
  • AI060890,
  • expressed sequence AW545884,
  • RIKEN cDNA 2700063L20 gene,
  • MGI:1917494,
  • Band 8A,
  • expressed sequence AI060890,
  • MGI:2145038,
  • MGI:3034420,
  • MGI:1922861,
  • C85228,
  • 2700063L20Rik,
  • mKIAA0044,
  • expressed sequence C85228,
  • B56/PP2A gamma,
  • AW545884,
  • Ppp2r5c,
  • DNA segment, Chr 12, Brigham & Women's Genetics 0916 expressed,
  • RIKEN cDNA 2610043M05 gene,
  • D12Bwg0916e,
  • MGD-MRK-34036,
  • MGI:2144759,
  • 2610043M05Rik,
  • MGI:106344,
  • protein phosphatase 2, regulatory subunit B', gamma

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