| Primary Identifier | IPR042716 | Type | Domain |
| Short Name | RNF114_RING-HC |
| description | RNF114 (also known as Znf313) is a p21(WAF1)-targeting ubiquitin E3 ligase that interacts with X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1) and may play a role in p53-mediated cell-fate decisions [, ]. It is involved in immune response to double-stranded RNA in disease pathogenesis []. Moreover, RNF114 interacts with A20 and modulates its ubiquitination []. It negatively regulates nuclear factor-kappaB (NF-kappaB)-dependent transcription and positively regulates T-cell activation []. RNF114 may play a putative role in the regulation of immune responses, since it corresponds to a novel psoriasis susceptibility gene, ZNF313 []. RNF114, together with three closely related proteins: RNF125, RNF138 and RNF166, forms a novel family of ubiquitin ligases with a C3HC4-type RING-HC finger, a C2HC-, and two C2H2-type zinc fingers, as well as a ubiquitin interacting motif (UIM). |
