| First Author | Banerjee A | Year | 2010 |
| Journal | J Immunol | Volume | 185 |
| Issue | 9 | Pages | 4988-92 |
| PubMed ID | 20935204 | Mgi Jnum | J:165175 |
| Mgi Id | MGI:4836412 | Doi | 10.4049/jimmunol.1002042 |
| Citation | Banerjee A, et al. (2010) Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche. J Immunol 185(9):4988-92 |
| abstractText | CD8(+) T cells responding to intracellular infection give rise to cellular progeny that become terminally differentiated effector cells and self-renewing memory cells. T-bet and eomesodermin (Eomes) are key transcription factors of cytotoxic lymphocyte lineages. We show in this study that CD8(+) T cells lacking Eomes compete poorly in contributing to the pool of Ag-specific central memory cells. Eomes-deficient CD8(+) T cells undergo primary clonal expansion but are defective in long-term survival, populating the bone marrow niche and re-expanding postrechallenge. The phenotype of Eomes-deficient CD8(+) T cells supports the hypothesis that T-bet and Eomes can act redundantly to induce effector functions, but can also act to reciprocally promote terminal differentiation versus self-renewal of Ag-specific memory cells. |
