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Allele : Pten<tm2Hwu> phosphatase and tensin homolog; targeted mutation 2, Hong Wu

Primary Identifier	MGI:3653409	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Pten
Transmission	Germline	Strain of Origin	129S4/SvJae
Is Recombinase	false	Is Wild Type	false

molecularNote

Deletion of exons 1-3 including both transcription and translation initiation sites was induced by homologous recombination.

mutations:
Intragenic deletion

cellLines:
Not Specified

synonyms:
Pten<->,
Pten<->

earliestPublication:
Sun H, et al. (1999) PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A 96(11):6199-204

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

6 Publication categories

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