| First Author | Takeda K | Year | 1999 |
| Journal | Science | Volume | 284 |
| Issue | 5412 | Pages | 313-6 |
| PubMed ID | 10195895 | Mgi Jnum | J:54315 |
| Mgi Id | MGI:1334922 | Doi | 10.1126/science.284.5412.313 |
| Citation | Takeda K, et al. (1999) Limb and skin abnormalities in mice lacking IKKalpha [see comments]. Science 284(5412):313-6 |
| abstractText | The gene encoding inhibitor of kappa B (IkappaB) kinase alpha (IKKalpha; also called IKK1) was disrupted by gene targeting. IKKalpha-deficient mice died perinatally. In IKKalpha-deficient fetuses, limb outgrowth was severely impaired despite unaffected skeletal development. The epidermal cells in IKKalpha-deficient fetuses were highly proliferative with dysregulated epidermal differentiation. In the basal layer, degradation of IkappaB and nuclear localization of nuclear factor kappa B (NF-kappaB) were not observed. Thus, IKKalpha is essential for NF-kappaB activation in the limb and skin during embryogenesis. In contrast, there was no impairment of NF-kappaB activation induced by either interleukin-1 or tumor necrosis factor-alpha in IKKalpha-deficient embryonic fibroblasts and thymocytes, indicating that IKKalpha is not essential for cytokine-induced activation of NF-kappaB. |
