| Primary Identifier | MGI:2389572 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 210766 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables metal-dependent deubiquitinase activity. Involved in chromatin remodeling and positive regulation of NLRP3 inflammasome complex assembly. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of BRCA1-A complex; BRISC complex; and nuclear ubiquitin ligase complex. Is expressed in central nervous system and genitourinary system. Orthologous to human BRCC3 (BRCA1/BRCA2-containing complex subunit 3). PHENOTYPE: Mice homozygous for a null allele exhibit reduced lethality in response to LPS treatment, decreased induced secretion of IL18 and IL1b, and impaired recruitment of neutrophils and monocytes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
