| First Author | Lim K | Year | 2009 |
| Journal | Biochem Biophys Res Commun | Volume | 380 |
| Issue | 3 | Pages | 569-74 |
| PubMed ID | 19285002 | Mgi Jnum | J:147063 |
| Mgi Id | MGI:3839183 | Doi | 10.1016/j.bbrc.2009.01.121 |
| Citation | Lim K, et al. (2009) O-GlcNAc inhibits interaction between Sp1 and Elf-1 transcription factors. Biochem Biophys Res Commun 380(3):569-74 |
| abstractText | The novel protein modification, O-linked N-acetylglucosamine (O-GlcNAc), plays an important role in various aspects of cell regulation. Although most of nuclear transcription regulatory factors are modified by O-GlcNAc, O-GlcNAc effects on transcription remain largely undefined yet. In this study, we show that O-GlcNAc inhibits a physical interaction between Sp1 and Elf-1 transcription factors, and negatively regulates transcription of placenta and embryonic expression oncofetal protein gene (Pem). These findings suggest that O-GlcNAc inhibits Sp1-mediated gene transcription possibly by interrupting Sp1 interaction with its cooperative factor. |
