| Primary Identifier | IPR034125 | Type | Domain |
| Short Name | RBM6_RRM2 |
| description | This entry represents the RNA recognition motif 2 (RRM2) of RBM6 (also known as lung cancer antigen NY-LU-12, or protein G16, or RNA-binding protein DEF-3), which has been predicted to be a nuclear factor based on its nuclear localization signal [, , ]. RBM6 shows high sequence similarity to RNA-binding protein 5 (RBM5). Both RBM6 and RBM5 specifically bind poly(G) RNA. They contain two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), two C2H2-type zinc fingers, a nuclear localization signal, and a G-patch/D111 domain. In contrast to RBM5, RBM6 has two additional unique domains: the decamer repeat occurring more than 20 times, and the POZ (poxvirus and zinc finger) domain. The POZ domain may be involved in protein-protein interactions and inhibit binding of target sequences by zinc fingers [, , ]. |
