| First Author | MacDonald GC | Year | 1995 |
| Journal | J Immunol | Volume | 154 |
| Issue | 1 | Pages | 444-9 |
| PubMed ID | 7527820 | Mgi Jnum | J:22258 |
| Mgi Id | MGI:70138 | Doi | 10.4049/jimmunol.154.1.444 |
| Citation | MacDonald GC, et al. (1995) In vivo depletion of Thy-1-positive cells originating from normal bone marrow abrogates the suppression of gld disease in normal-gld mixed bone marrow chimeras. J Immunol 154(1):444-9 |
| abstractText | Mice homozygous for gld develop an autoimmune syndrome characterized by hypergammaglobulinemia, massive accumulation of abnormal T cells and the production of autoantibodies. Previous studies in our laboratory have shown that reconstitution of lethally irradiated B6/gld recipients with a mixture of normal and gld bone marrow (BM) suppresses the gld-induced syndrome. In this report we extend this observation by demonstrating that the depletion of normal Thy-1+ cells, but not normal B cells, restores gld disease in mixed BM chimeras congenic for Thy-1 and IgH alleles. These results strongly suggest that normal T cells suppress the development of gld-related abnormalities. It is probable that the mechanism by which normal Thy-1+ cells mediate the suppression is Fas ligand dependent. |
