| First Author | Ghimire SR | Year | 2018 |
| Journal | Development | Volume | 145 |
| Issue | 12 | PubMed ID | 29784671 |
| Mgi Jnum | J:264107 | Mgi Id | MGI:6191855 |
| Doi | 10.1242/dev.159012 | Citation | Ghimire SR, et al. (2018) A non-autonomous function of the core PCP protein VANGL2 directs peripheral axon turning in the developing cochlea. Development 145(12):dev159012 |
| abstractText | The cochlea is innervated by neurons that relay sound information from hair cells to central auditory targets. A subset of these are the type II spiral ganglion neurons, which have nociceptive features and contribute to feedback circuits providing neuroprotection in extreme noise. Type II neurons make a distinctive 90 degrees turn towards the cochlear base to synapse with 10-15 outer hair cells. We demonstrate that this axon turning event requires planar cell polarity (PCP) signaling and is disrupted in Vangl2 and Celsr1 knockout mice, and that VANGL2 acts non-autonomously from the cochlea to direct turning. Moreover, VANGL2 is asymmetrically distributed at intercellular junctions between cochlear supporting cells, and in a pattern that could allow it to act directly as an axon guidance cue. Together, these data reveal a non-autonomous function for PCP signaling during axon guidance occurring in the tissue that is innervated, rather than the navigating growth cone. |
