| First Author | Feng Y | Year | 1997 |
| Journal | Biochem Biophys Res Commun | Volume | 231 |
| Issue | 3 | Pages | 651-4 |
| PubMed ID | 9070864 | Mgi Jnum | J:38628 |
| Mgi Id | MGI:86014 | Doi | 10.1006/bbrc.1997.6161 |
| Citation | Feng Y, et al. (1997) Cloning of a novel member of the G protein-coupled receptor family related to peptide receptors. Biochem Biophys Res Commun 231(3):651-4 |
| abstractText | We have used PCR with degenerate oligonucleotide primers to clone novel members of the G protein-coupled receptor (GPCR) superfamily. We report here a novel gene, CEPR, which encodes a candidate receptor that is most similar to the peptide receptor family. The coding region of the human CEPR gene predicts a seven transmembrane domain (TM) receptor of 375 amino acids. CEPR has 28-30 percent amino acid identity to angiotensin II and interleukin 8 receptors, and slightly lower percent identity to many other GPCRs. Northern blot analysis reveals a 3.3 kb CEPR transcript in different regions of human brain and in various peripheral tissues. The ubiquitous tissue distribution of CEPR, its expression in early development, and its conservation in evolution indicate a potentially important biological function for this receptor and its putative peptide ligand. |
