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Protein Coding Gene : Kif18a kinesin family member 18A
Primary Identifier  MGI:2446977 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  228421
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Predicted to enable several functions, including ATP hydrolysis activity; cytoskeletal protein binding activity; and plus-end-directed microtubule motor activity. Acts upstream of or within nuclear division; regulation of microtubule cytoskeleton organization; and seminiferous tubule development. Located in kinetochore and mitotic spindle midzone. Is expressed in central nervous system; gonad; and retina. Orthologous to human KIF18A (kinesin family member 18A).
PHENOTYPE: Mice homozygous for loss of function alleles exhibit reduced female fertility and male infertility due to primordial germ cell depletion. The sterility phenotype is incompletely penetrant, has variable expressivity, and is modulated by strain background. [provided by MGI curators]
  • synonyms:
  • MGI:3050505,
  • kinesin family member 18A,
  • AU024633,
  • N-8 kinesin,
  • Kif18a,
  • RIKEN cDNA B130001M12 gene,
  • germ cell depletion 2,
  • expressed sequence AU024633,
  • B130001M12Rik,
  • MGI:2444495,
  • gcd2,
  • MGI:2139208,
  • MGC:27627
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Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

3 Involved In Mutations

Trail: ProteinCodingGene

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

29 Pathways

Trail: ProteinCodingGene

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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0 Driver For





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