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Allele : Flt3<tm2.1Dosm> FMS-like tyrosine kinase 3; targeted mutation 2.1, Donald Small
Primary Identifier  MGI:5565506 Allele Type  Targeted
Attribute String  Constitutively active Gene  Flt3
Transmission  Germline Strain of Origin  129
Is Recombinase  false Is Wild Type  false
molecularNote  An inverted floxed pgk-neo cassette was inserted in intron 19 and codon 838 was changed to TAC from TAT in exon 20 via homologous recombination. This results in a D838Y mutation corresponding to the D835Y mutation seen in patients with acute myeloid leukemia. Cre mediated recombination removed the neo cassette.
  • mutations:
  • Insertion,
  • Single point mutation
  • synonyms:
  • FLT3/D835Y,
  • FLT3/D835Y
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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1 Carried By

Trail: Allele

0 Driven By

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Trail: Allele




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