| Primary Identifier | MGI:5565509 | Allele Type | Targeted |
| Attribute String | Conditional ready, Constitutively active | Gene | Flt3 |
| Transmission | Germline | Strain of Origin | 129 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | An inverted floxed pgk-neo cassette was inserted in intron 19 and codon 838 was changed to TAC from TAT in exon 20 via homologous recombination. This results in a D838Y mutation corresponding to the D835Y mutation seen in patients with acute myeloid leukemia. Removal of the neo cassette increases expression and activity of this allele. |
