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Protein Coding Gene : Ubr4 ubiquitin protein ligase E3 component n-recognin 4
Primary Identifier  MGI:1916366 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  69116
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of fatty acid biosynthetic process and ubiquitin-dependent protein catabolic process. Predicted to be located in several cellular components, including cytoplasm; cytoskeleton; and nucleus. Predicted to be active in centrosome; cytosol; and nucleoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human UBR4 (ubiquitin protein ligase E3 component n-recognin 4).
PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit neonatal lethality and decreased body size at birth. Mice homozygous for a null mutation display complete embryonic lethality during organogenesis with arrest of vitelline vascular remodeling. [provided by MGI curators]
  • synonyms:
  • expressed sequence N28143,
  • Ubr4,
  • mKIAA0462,
  • p600,
  • LOC381562,
  • RIKEN cDNA A930005E13 gene,
  • D930005K06Rik,
  • Zubr1,
  • MGI:2685878,
  • N28143,
  • MGI:2140710,
  • gene model 1032, (NCBI),
  • RIKEN cDNA D930005K06 gene,
  • ubiquitin protein ligase E3 component n-recognin 4,
  • 1810009A16Rik,
  • zinc finger, UBR1 type 1,
  • MGI:2444481,
  • RIKEN cDNA 1810009A16 gene,
  • A930005E13Rik,
  • Gm1032
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