| First Author | Kobielak A | Year | 2004 |
| Journal | Nat Cell Biol | Volume | 6 |
| Issue | 1 | Pages | 21-30 |
| PubMed ID | 14647292 | Mgi Jnum | J:87710 |
| Mgi Id | MGI:3027450 | Doi | 10.1038/ncb1075 |
| Citation | Kobielak A, et al. (2004) Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables. Nat Cell Biol 6(1):21-30 |
| abstractText | During epithelial sheet formation, linear actin cables assemble at nascent adherens junctions. This process requires alpha-catenin and actin polymerization, although the underlying mechanism is poorly understood. Here, we show that formin-1 interacts with alpha-catenin, localizes to adherens junctions and nucleates unbranched actin filaments. Furthermore, disruption of the alpha-catenin-formin-1 interaction blocks assembly of radial actin cables and perturbs intercellular adhesion. A fusion protein of the beta-catenin-binding domain of alpha-catenin with the actin polymerization domains of formin-1 rescues formation of adherens junctions and associated actin cables in alpha-catenin-null keratinocytes. These findings provide new insight into how alpha-catenin orchestrates actin dynamics during intercellular junction formation. |
