| Primary Identifier | IPR031824 | Type | Domain |
| Short Name | RNF220_mid |
| description | This entry represents the central region of the E3 ubiquitin-protein ligase RNF220 []. RNF220 also interacts with beta-catenin independently of its E3 ligase activity; instead of ubiquitinating and destabilising it, RNF220 promotes beta-catenin stabilisation and canonical Wnt signaling []. Proteins containing this domain also include Drosophila Tey protein and some uncharacterised fungal proteins. Tey (Teyrha-Meyhra) is a transcription factor that suppresses Toll expression []. |
