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Protein Coding Gene : H1f4 H1.4 linker histone, cluster member
Primary Identifier  MGI:1931527 Organism  mouse, laboratory
Chromosome  13 NCBI Gene Number  50709
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables DNA binding activity. A structural constituent of chromatin. Acts upstream of or within chromatin organization and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in early conceptus and oocyte. Orthologous to human H1-4 (H1.4 linker histone, cluster member).
PHENOTYPE: Homozygotes for targeted null mutations are normal, but Hist1h1e/Hist1h1c double knockout males are significantly smaller than normal. The Hist1h1e/Hist1h1d/Hist1h1e triple knockout is lethal by embryonic day 12.5, and heterozygotes are underrepresented. [provided by MGI curators]
  • synonyms:
  • H1e,
  • Hist1h1e,
  • H1.4 linker histone, cluster member,
  • H1 histone family, member 4,
  • H1f4,
  • H1s-4,
  • histone cluster 1, H1e,
  • H1-4,
  • H1var2
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Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

1 Genomic Clusters

Trail: ProteinCodingGene

2 Involved In Mutations

Trail: ProteinCodingGene

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

9 Pathways

Trail: ProteinCodingGene

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For





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