| First Author | Tomanek RJ | Year | 2015 |
| Journal | Anat Rec (Hoboken) | Volume | 298 |
| Issue | 2 | Pages | 408-17 |
| PubMed ID | 25266175 | Mgi Jnum | J:217298 |
| Mgi Id | MGI:5613729 | Doi | 10.1002/ar.23056 |
| Citation | Tomanek RJ, et al. (2015) Coronary anomalies in mice with congenital heart defects. Anat Rec (Hoboken) 298(2):408-17 |
| abstractText | BACKGROUND: Coronary anomalies are frequently associated with congenital cardiac defects. Accordingly, we tested the hypothesis that the development of the tunica media of coronary arteries/arterioles is compromised in mice with cardiac defects of the outflow tract (persistent truncus arteriosus, double outlet right ventricle and transposition of the great arteries) by studying hearts of G7-9 generation mice bred from mutagenized mice caused by N-ethyl-N-nitrosourea. Mice were studied at embryonic days E16.5, E17.5, and postnatal days 1 and 11. Data were based on immunohistochemistry of serial sections. RESULTS: In 21 of 24 mice with outflow tract defects, the development of smooth muscle in arteries and arterioles was retarded; most commonly arterioles had an incomplete layer of smooth muscle or in a few instances, lacked a tunica media. In this model, an absence of a coronary ostium occurred in only 2 mice, indicating that the mechanisms underlying the formation of coronary ostia and the recruitment and differentiation of vascular smooth muscle differ. Coronary fistulas were present in 20% and dilated vessels in 30% of the hearts with cardiac defects. CONCLUSIONS: The data suggest that vascular smooth muscle recruitment and differentiation are not necessarily linked to other coronary anomalies, such as absence of a main coronary artery or branching patterns. Anat Rec, 298:408-417, 2015. (c) 2014 Wiley Periodicals, Inc. |
