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Protein Coding Gene : Arpp21 cyclic AMP-regulated phosphoprotein, 21

Primary Identifier  MGI:107562 Organism  mouse, laboratory
Chromosome  9 NCBI Gene Number  74100
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Predicted to enable calmodulin binding activity and nucleic acid binding activity. Acts upstream of or within cellular response to heat. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; limb segment; sensory organ; and tail. Orthologous to human ARPP21 (cAMP regulated phosphoprotein 21).
PHENOTYPE: Homozygous null mice are viable and display normal brain anatomy and no obvious behavioral or morphological defects. However, in medium spiny neurons from mutant mice, the ability of both M1 and D2 receptor activation to modulate L-type calcium channel currents is enhanced by nearly 2-fold. [provided by MGI curators]
  • synonyms:
  • DNA segment, Chr 9, Brigham & Women's Genetics 1012 expressed,
  • MGD-MRK-36134,
  • MGD-MRK-34106,
  • 0710001E13Rik,
  • AI853636,
  • MGI:2143158,
  • MGI:106412,
  • ARPP-21,
  • R3hdm3,
  • RIKEN cDNA 0710001E13 gene,
  • MGI:1921350,
  • Tarpp,
  • D9Bwg1012e,
  • expressed sequence AI853636,
  • Arpp21,
  • cyclic AMP-regulated phosphoprotein, 21,
  • MGI:1935000

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